Top 10 Funding Rounds Led by AI, Cybersecurity and Health This Week

Follow our curated index of $100 million-plus venture investments in U.S.-based companies throughout 2026 using The Crunchbase Megadeals Board.

Each week, this recurring feature highlights the ten largest announced funding rounds within the United States. You can review the previous week’s largest funding deal roundup here.

This week brought a rich assortment of massive startup investments, highlighted by a pair of $400 million capital raises for cybersecurity unicorns Island and Cyera. Additional sizable financings went to emerging companies across active sectors including foundational AI, drug discovery, neurotech, and cloud seeding.

1. Island, $400M, cybersecurity: Dallas-based Island, a creator of secure enterprise digital operation tools, secured $400 million in a Series F round. Evolution Equity Partners spearheaded the financing, pushing the company’s valuation to $6.4 billion—more than double its 2024 worth.

2. Cyera, $400M, cybersecurity: New York-based Cyera, an enterprise data security platform that manages both human users and AI agents, gathered $400 million through a Series G extension. Evolution Equity Partners led the investment, with backing from Goldman Sachs Growth Equity, bringing Cyera’s total raised capital to $2.7 billion according to Crunchbase figures.

3. Snorkel AI, $350M, foundational AI: San Francisco’s Snorkel AI supplies specialized training data and development environments for frontier laboratories and AI teams. The 7-year-old enterprise pulled in $350 million in Series E funding, led by Insight Partners and S32, which values the firm at $3.2 billion and establishes its annual recurring revenue at above $375 million.

4. Enveda, $311M, biotech: Boulder, Colorado-based Enveda utilizes artificial intelligence for drug discovery and finalized a $311 million Series E financing. Catalio Capital Management steered the investment alongside a broad network of new and returning backers, lifting the company’s lifetime capital raised past $845 million.

5. Precision Neuroscience, $250M, neurotech: Operating out of New York, brain-computer interface developer Precision Neuroscience collected $250 million via Series D funding. Pershing Square and the Ackman Oxman Institute acted as the lead investors for the round.

6. Hubble Network, $200M, wireless communications: Satellite network operator Hubble Network delivers connectivity extensions to standard Bluetooth hardware and secured $200 million in Series C financing. Smith Point Capital directed the investment, establishing a $1.6 billion valuation for the Seattle-headquartered enterprise.

7. Rightway, $155M, pharmacy benefits: New York-based pharmacy benefits and care navigation manager Rightway completed a $155 million Series E round driven by Francisco Partners. The company plans to dedicate a portion of the capital toward scaling its artificial intelligence functions.

8. (tied) Rainmaker, $100M, cloud seeding: El Segundo, California-based Rainmaker specializes in atmospheric research and generates new freshwater supplies via cloud seeding, landing $100 million in Series B financing. Participants in the round consist of Noa, Upfront Ventures, DCVC, Lowercarbon Capital, and Dream Ventures.

8. (tied) Numeral, $100M, tax compliance: Artificial intelligence-driven sales tax compliance platform Numeral, based in San Francisco, finalized a $100 million Series C investment led by Insight Partners.

8. (tied) Micro1, $100M, AI data: San Francisco-located Micro1 supplies artificial intelligence training data to leading AI labs and reportedly completed a new investment exceeding $100 million. A Forbes report citing sources close to the transaction places the company’s valuation at $4 billion.

Methodology

We monitored the biggest reported funding transactions listed in the Crunchbase database for U.S.-headquartered companies between September 19 and September 25, 2026. While the vast majority of announcements are captured promptly, minor delays can occur when transactions are disclosed toward the end of the week.

Illustration: Dom Guzman

Frequently Asked Questions

What were the largest funding rounds of the week?

The top spots were led by two $400 million investments in cybersecurity unicorns Island and Cyera, followed by Snorkel AI at $350 million and Enveda at $311 million.

Which sectors dominated this week’s venture deals?

Cybersecurity, foundational AI, biotech drug discovery, neurotech, wireless communications, and cloud seeding were among the prominent sectors securing massive funding.

How is this weekly data compiled?

The data tracks the largest announced financing rounds raised by U.S.-based companies within the Crunchbase database for the specified weekly timeframe.

Are all funding rounds included immediately?

Most announcements are captured in the database, though a slight time lag may occur for deals reported late in the week.

Where can I view previous megadeals?

You can reference past roundups and explore ongoing major transactions via The Crunchbase Megadeals Board.